![]() Certain features of the LINE-1 (L1) retrotransposon-encoded ORF1 protein (ORF1p) are analogous to those of neurodegeneration-associated RNA-binding proteins, including formation of cytoplasmic aggregates. Several studies have drawn connections between altered retrotransposon expression and ALS. 9 MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Western General Hospital, Edinburgh, UK.Īmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease involving loss of motor neurons and having no known cure and uncertain etiology.8 8Department of Human Genetics, Medical Faculty, University of Saarland, Homburg/Saar, Germany.7 7Department of Biochemistry and Molecular Biology II, Faculty of Pharmacy, University of Granada, Granada, Spain.6 6Neuromuscular Division, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.5 5Department of Neurosciences, School of Medicine, University of California at San Diego, San Diego, California USA.4 4School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), CH-1015 Lausanne, Switzerland.3 3Oncology Center-Cancer Biology, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, Granada, Spain. 1 1McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland USA.It hosts monthly card parties, local church events, private celebrations, and community gatherings. Today the Wild Horse School-located on US 40/287 just north of the Wild Horse Post Office-is owned by Cheyenne County and continues to be used as a community center. The Wild Horse Community Club acquired the schoolhouse and used it for reunions, political meetings, and other events. The Wild Horse School closed, and local students started to attend elementary school in Kit Carson. In 1964 Cheyenne County consolidated its schools. The larger, modernized schoolhouse once again became a popular site for community events. The connecting hall between the buildings included restrooms and a kitchen, and the newly joined extension continued to be used as a dining area. At the same time, the building was renovated to add indoor plumbing, heating, and electricity. In 1959 the two buildings were joined, making a single schoolhouse with a slightly offset T-shape. In 1934 a separate one-room schoolhouse from Lost Springs, in northern Cheyenne County, was moved to Wild Horse and placed behind the existing school, where it served as a lunchroom. The Wild Horse School has received one major addition since it was built. After that the school offered ninth and tenth grades for a few years before reverting to only grades 1–8. In 1921 Charles Heffner deeded the schoolhouse to the local school district. Initially the schoolhouse also hosted a variety of social and civic events, but after 1920 most community activities were moved to the new Wild Horse Community Hall. The Wild Horse School served the area’s population of largely northern European immigrants-Norwegians, Germans, Irish, and others-who worked on the railroad or were involved in the local ranching and farming industries. In 1917 a fire devastated Wild Horse, but the school’s location north of town saved it from destruction. The school usually had two teachers, with grades 1–4 in one classroom and grades 5–8 in the other. ![]() Inside, a cloakroom had two doors leading to separate classrooms of equal size. Completed in 1912, the wood-frame building faced south and featured a small bell tower above the central entry. As Wild Horse continued to grow, in 1911 Charles Heffner hired Gustav Sanders to build a two-room schoolhouse north of town. At first, a house owned by John Goodier served as the town’s school. In 1907 Wild Horse formed a school district. The town quickly added hotels, banks, and stores. In 1905 Wild Horse Station got its first postmaster, and in 1906 the town of Wild Horse was surveyed. The town of Wild Horse traces its origins to 1869, when a cavalry unit found a herd of wild horses at a watering hole and named the spot Wild Horse Station. Since it stopped being a school, the building has continued to serve Wild Horse as a community center, and in 1996 it was listed on the State Register of Historic Properties. Originally a two-room building, the schoolhouse was expanded when a separate one-room structure was moved to the site in 1934 and connected to the school in 1959. The Wild Horse School was built in 1911–12 and served until 1964 as the only school in the town of Wild Horse (8513 State Hwy 40 287, Wild Horse, CO 80862), in Cheyenne County. ![]()
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